Can plasminogen activators be improved?

Editorial Comment Can Plasminogen Activators Be Improved?

T he widespread application of plasminogen activators in the treatment of myocardial infarction has resulted in a significant reduction in mortality.",2 Most patients have been treated with two very different drugs: streptokinase, a bacterial protein that is the product of fermentation technology dating from the 1930s, and recombinant tissue-type plasminogen activator (rt-PA), a human protein t...

Retinal pigment epithelium cells can influence endothelial cell plasminogen activators.

Endothelial cells from both human retinal microvessels (HME) and fetal bovine aortic endothelium (FBAE) were grown in aggregate cultures alone, or with either retinal pigment epithelium (RPE) cells or fibroblasts. The levels of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) in the conditioned media of the various aggregate types were measured. High PA levels were detected ...

Bacterial plasminogen activators and receptors.

Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and th...

Can Male Fertility Be Improved Prior to Assisted Reproduction through The Control of Uncommonly Considered Factors?

O10: How Child Protection in Cars Can be Improved in Iran? Suggested Approach

The presentation will focus on the key areas that are essential to build a comprehensive policy towards reducing child injury and fatalities. The presentation will focus on the importance of the public awareness (education on the use of child restraint systems), the need to have an overall road safety programme, law enforcement (mandatory use of protection systems for children in car) and final...